When the lads go out for a curry after a few beers, it is often a challenge to see who can manage the hottest curry. I don't think I have a genetic advantage based on my DNA, but I should have a cultural advantage based on decades of tastebud desensitisation.
Unfortunately research proves that it is birds who can manage the hottest - chilis that would make not just my eyes but my whole head water are just tasteless vegetables for some.
I've said before, the word hot is definitely misleading, arguably just wrong. The word should be jhal.